Bone remodeling is a complex process regulated by various mediators. Cytokines are known to be associated with the mechanically induced response in orthodontic tooth movement. In particular, IL-1.8 stimulates bone resorption and induces osteoclast proliferation. The purpose of this study was to identify and quantify IL-1,8 in human gingival crevicular fluid(GCF), and to investigate the changes in its level during orthodontic tooth movement. Twelve patients(mean age of 19.2 years) were used as the subjects. An upper canine of each patient having treatment for distal movements served as the experimental tooth, whereas the contralateral was used as the control. The GCF of compression and tension side of the experimental teeth and the GCF of mesial side of control teeth was taken from the each subject immediately before activation, and at 1, 24, and 168 hr after initiation tooth movement. IL-1.8 amount was. detected by ELISA. The concentration of IL-1,8 was higher in experimental group than in, the control group after treatment. Its level was elevated after initiation of tooth movement and it was the highest level at 24 hr in compression side of experimental group, But there was no significant change in control group.
The results ´ndicate that the change in IL-19 level in GCF is associated with orthodontic tooth movement.
|